Skin Eruption with Gabapentin in a Patient with Repeated AED-Induced Stevens-Johnson's Syndrome
作者:
John DeToledo,
Alireza Minagar,
Meredith Lowe,
R. Ramsay,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1999)
卷期:
Volume 21,
issue 1
页码: 137-138
ISSN:0163-4356
年代: 1999
出版商: OVID
关键词: Gabapentin;Stevens-Johnson's syndrome;Antiepileptic drugs;Rash;Allergy;Skin eruptions
数据来源: OVID
摘要:
Skin eruptions have been reported with the use of all antiepileptic drugs and there is a significant risk of cross-reactivity between these agents in causing serious eruptions such as Stevens-Johnson's Syndrome. Gabepentin is usually considered a safe agent for patients with a previous history of drug allergies and there have been no cases of skin eruption reported to the gabapentin post marketing surveillance. We report a patient who had severe Stevens-Johnson's Syndrome induced by phenytoin and later by carbamazepine. Subsequent use of gabapentin also resulted in a skin eruption which was limited to the lower extremities but without systemic or mucosal involvement. This case suggests that patients with a strong history of drug-induced idiosyncratic reactions may experience such reactions to gabapentin as well.
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