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Skin Eruption with Gabapentin in a Patient with Repeated AED-Induced Stevens-Johnson's Syndrome

 

作者: John DeToledo,   Alireza Minagar,   Meredith Lowe,   R. Ramsay,  

 

期刊: Therapeutic Drug Monitoring  (OVID Available online 1999)
卷期: Volume 21, issue 1  

页码: 137-138

 

ISSN:0163-4356

 

年代: 1999

 

出版商: OVID

 

关键词: Gabapentin;Stevens-Johnson's syndrome;Antiepileptic drugs;Rash;Allergy;Skin eruptions

 

数据来源: OVID

 

摘要:

Skin eruptions have been reported with the use of all antiepileptic drugs and there is a significant risk of cross-reactivity between these agents in causing serious eruptions such as Stevens-Johnson's Syndrome. Gabepentin is usually considered a safe agent for patients with a previous history of drug allergies and there have been no cases of skin eruption reported to the gabapentin post marketing surveillance. We report a patient who had severe Stevens-Johnson's Syndrome induced by phenytoin and later by carbamazepine. Subsequent use of gabapentin also resulted in a skin eruption which was limited to the lower extremities but without systemic or mucosal involvement. This case suggests that patients with a strong history of drug-induced idiosyncratic reactions may experience such reactions to gabapentin as well.

 



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