Nitroprusside‐induced Cyanide PoisoningAntidotal Effect of Hydroxocobalamin
作者:
Mark Posner,
F. Rodkey,
Raymond Tobey,
期刊:
Anesthesiology
(OVID Available online 1976)
卷期:
Volume 44,
issue 4
页码: 330-335
ISSN:0003-3022
年代: 1976
出版商: OVID
关键词: Toxicity;cyanide; Biotrans-formation;nitroprusside; Anesthetic techniques;hypotension;induced;nitroprusside; Pharmacology;hydroxocobalamin
数据来源: OVID
摘要:
Sodium nitroprusside was investigated as a potential source of cyanide poisoning. Whole-blood cyanide determinations were performed on arterial samples from baboons receiving nitroprusside while anesthetized. There was a statistically significant increase in cyanide levels, as well as development of tachyphylaxis and severe metabolic acidosis. Hydroxocobalamin (vitamin B12a) infused simultaneously with nitroprusside significantly lessened the increase in cyanide levels and eliminated the development of metabolic acidosis. Nitroprusside can cause cyanide intoxication in the baboon, and hydroxocobalamin appears to be an effective antidote.
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