首页   按字顺浏览 期刊浏览 卷期浏览 Limitation of theophylline elimination by reduced oxygen availability in mouse hepatocy...
Limitation of theophylline elimination by reduced oxygen availability in mouse hepatocytes and rat isolated livers

 

作者: Kanji Nakatsu,  

 

期刊: Canadian Journal of Physiology and Pharmacology  (NRC Available online 1985)
卷期: Volume 63, issue 8  

页码: 903-907

 

ISSN:0008-4212

 

年代: 1985

 

DOI:10.1139/y85-149

 

出版商: NRC Research Press

 

数据来源: NRC

 

摘要:

The effect of oxygen availability on theophylline metabolism by mouse hepatocytes and rat isolated livers was examined. The elimination of theophylline by mouse hepatocytes and the metabolism of theophylline to dimethyluric acid by isolated, perfused rat livers was seriously impaired when the gas mixture supplied contained less than 28% oxygen. The correlation coefficients relating oxygen supply and the concentration of theophylline remaining in mouse hepatocyte suspensions were −0.74 to −0.84. In the isolated, perfused rat liver experiments, the correlation coefficient relating oxygen availability and dimethyluric acid production was 0.87. These observations are interpreted as supporting the hypothesis that oxygen availability per se is an important factor in determining the rate of theophylline metabolism.

 

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