Caffeine Reversal of Length‐Dependent Changes in Myocardial Contractile State in the Cat
作者:
LEONARD CHUCK,
WILLIAM PARMLEY,
期刊:
Circulation Research
(OVID Available online 1980)
卷期:
Volume 47,
issue 4
页码: 592-598
ISSN:0009-7330
年代: 1980
出版商: OVID
数据来源: OVID
摘要:
The present study evaluated potential mechanisms for the slow length-dependent change in myocardial contractile state. Using 40 isolated right ventricular cat papillary muscles, we found that 10 mM caffeine reversed the subsequent slow change in myocardial performance following a change in muscle length. Since caffeine acts both at the sarcolemma and the sarcoplasmic reticulum, we atten-uated the sarcolemmal influx of calcium with verapamil, manganese, and low external calcium concen-tration. None of these interventions altered the caffeine reversal of the length-dependent effect. It thus appears that the length-dependent alteration of contractile state is of intracellular origin, and probably related to altered calcium handling by the sarcoplasmic reticulum.Circ Res 47: 592-598, 1980
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