A Study of the Relationship betweenex vivoandin vivoEffects of Sulphinpyrazone in the Guinea Pig
作者:
K.D. Butler,
R.B. Wallis,
A.M. White,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 353-360
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214325
出版商: S. Karger AG
关键词: Sulphinpyrazone;Platelets;Aggregation
数据来源: Karger
摘要:
In guinea pigs, sodium arachidonate-induced platelet aggregation ex vivo proved a more sensitive method for detecting drug-related effects after the administration of sulphinpyrazone than collagen-induced platelet aggregation. It was possible to detect inhibition of platelet aggregation after giving sulphinpyrazone orally in a single dose of 3 mg/kg. Excellent correlation was achieved between ex vivo and in vivo inhibition of platelet function with sulphinpyrazone using the Arthus reaction. The results are consistent with the formation, in the guinea pig of metabolites more potent than the parent molecule.
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