Fusidic Acid and Insulin-Dependent Diabetes Mellitus
作者:
NicolettiFerdinando,
LuigiPier,
BendtzenKlaus,
期刊:
Autoimmunity
(Taylor Available online 1996)
卷期:
Volume 24,
issue 3
页码: 187-197
ISSN:0891-6934
年代: 1996
DOI:10.3109/08916939608995364
出版商: Taylor&Francis
关键词: insulin-dependent diabetes mellitus;fusidic acid;treatment;immunosuppression
数据来源: Taylor
摘要:
Insulin-dependent diabetes mellitus (IDDM) is a major cause of morbidity and mortality from long-standing complications. The autoimmune nature of IDDM has encouraged use of immunosuppressive and antiinflammatory strategies to better preserve residual pancreatic p-cell function at the time of diagnosis. Fusidic acid and its sodium salt, fusidin, is a relatively atoxic antibiotic used mainly in the treatment of staphylococcal infections. Recently, fusidin has been demonstrated to possess immunosuppressive functionsin vitroandin vivo, and the drug has shown promise in preventing the disease in animal models of IDDM and in a preliminary trial in IDDM patients.
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