Studies on Human Semen in Topical Corticosteroid-Treated and in Methotrexate-Treated Psoriatics
作者:
E. Grunnet,
A. Nyfors,
Brogaard Hansen,
期刊:
Dermatology
(Karger Available online 1977)
卷期:
Volume 154,
issue 2
页码: 78-84
ISSN:1018-8665
年代: 1977
DOI:10.1159/000251036
出版商: S. Karger AG
关键词: Psoriasis;Sperm analysis;Topical corticosteroids;Methotrexate
数据来源: Karger
摘要:
Ejaculates were studied from ten men with severe psoriasis treated with topical corticosteroids and from ten similar patients who had received methotrexate therapy from 1 to 9 years. It was not possible to demonstrate any unfavorable effect on the semen quality during the methotrexate therapy. The semen analysis was more frequently found normal (p = 0.04) in the methotrexate treated group, and no specific abnormality was found in spermatozoa of methotrexate-treated patients. Methotrexate therapy to male psoriatics seems safe and in agreement with this no congenital abnormalities have been reported. A remarkable number of the ejaculates had reduced sperm qualities, and it is proposed that this might be due to psoriatic lesions in the genital tract.
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