Comparison of 7 Versus 10 Days of Antibiotic Therapy for Hospitalized Patients with Uncomplicated Community‐Acquired PneumoniaA Prospective, Randomized, Double‐Blind Study
作者:
Robert,
Siegel Margarita,
Alicea Alice,
Lee Robert,
期刊:
American Journal of Therapeutics
(OVID Available online 1999)
卷期:
Volume 6,
issue 4
页码: 217-222
ISSN:1075-2765
年代: 1999
出版商: OVID
关键词: community-acquired pneumonia;cefuroxime;treatment.
数据来源: OVID
摘要:
The objective of this study was to compare the outcome of 7 versus 10 days of antibiotic therapy for inpatients with moderately severe community-acquired pneumonia (CAP). A prospective, randomized, double-blind study with a follow-up period of 42 days was conducted. Fifty-two veterans were treated with 2 days of cefuroxime at 750 mg intravenously every 8 hours followed by group 1, 8 days oral therapy, and group 2, 5 days oral therapy followed by 3 days of placebo. Oral therapy consisted of cefuroxime axetil at 500 mg every 12 hours. No difference was seen in cure rates: 20 of 22 (90.9%) patients in group 1 and 21 of 24 (875%) patients in group 2. There were no late recurrences. Potential US cost-savings is $27.2 million. Inpatients with moderately severe CAP can be treated with 2 days of intravenous antibiotics followed by 5 additional days of oral antibiotics. Longer treatment duration prolongs the cost of care, without increasing the cure rate or decreasing the pneumonia recurrence rate.
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