Diagnosis When the Gene Locus Is Unknown
作者:
WhiteRaymond L.,
期刊:
Hospital Practice
(Taylor Available online 1985)
卷期:
Volume 20,
issue 5
页码: 103-113
ISSN:2154-8331
年代: 1985
DOI:10.1080/21548331.1985.11703058
出版商: Taylor&Francis
数据来源: Taylor
摘要:
For genetic diagnosis of conditions in which the affected gene cannot be identified, we must fall back on the technique of linkage—but with a difference. Work with restriction enzymes has produced a near-revolution in clinical genetics; it has enormously increased the number of traits accessible to evaluation by linkage with identifiable DNA polymorphisms.
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