Restoration of Doxorubicin Responsiveness in Doxorubicin-Resistant P388 Murine Leukaemia Cells by Dipyrone
作者:
Manik P. Chitnis,
Narayana S. Kamath,
期刊:
Oncology
(Karger Available online 1987)
卷期:
Volume 44,
issue 1
页码: 47-50
ISSN:0030-2414
年代: 1987
DOI:10.1159/000226442
出版商: S. Karger AG
关键词: Drug resistance;Doxorubicin;Mitoxantrone;Dipyrone;Synergistic action;P388 leukaemia
数据来源: Karger
摘要:
The effect of dipyrone along with doxorubicin and mitoxantrone was studied alone and in combination on the 3H-thymidine (3H-TdR) incorporation in P388 leukaemia sensitive (P388/S) and resistant (P388/ADR) to doxorubicin. Dipyrone 10––4M demonstrated minimal inhibitory effect on DNA biosynthesis in both the sensitive and resistant cells. Doxorubicin and mitoxantrone at equimolar concentrations, indicated time and dose-dependent inhibition in 3H-TdR incorporation in the sensitive cells. The inhibition was more at the higher drug concentrations at 4 h drug exposure. Mitoxantrone showed cross-resistance in P388/ADR compared to P388/S. Both the drugs along with 10––4M dipyrone in the incubating medium revealed synergistic inhibitory activity in P388/S and P388/ADR. Observations indicate circumvention of doxorubicin and mitoxantrone resistance in P388/ADR by d
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