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Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus

 

作者: W. Tetzlaff,   M. B. Graeber,   M. A. Bisby,   G. W. Kreutzberg,  

 

期刊: Glia  （WILEY Available online 1988）
卷期: Volume 1, issue 1  

页码: 90-95

 

ISSN:0894-1491

 

年代: 1988

 

DOI:10.1002/glia.440010110

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: 2D Gel electrophoresis;Motoneuron regeneration;Facial nucleus

 

数据来源: WILEY

 

摘要:

AbstractGlial fibrillary acidic protein (GFAP) increases in astrocytes following axotomy of facial motoneurons. In the present study we quantified GFAP synthesis both in regenerating facial nuclei after nerve crush and in nonregenerating facial nuclei after nerve resection. An increase in GFAP synthesis during regeneration occurs as early as 24 h after the axotomy. Thus, the increase in the astrocytic GFAP synthesis seems to be the earliest glial response to retrograde changes in facial motoneurons.

 

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