Hydrocortisone modulates RA‐induced growth inhibition of normal and transformed human embryonic lung fibroblasts
作者:
Stanulis‐PraegerBetzabéM.,
JacobusClaireH.,
NuttallAnneE.,
期刊:
Nutrition and Cancer
(Taylor Available online 1986)
卷期:
Volume 8,
issue 3
页码: 171-184
ISSN:0163-5581
年代: 1986
DOI:10.1080/01635588609513891
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractAll‐trans retinoic acid (10−5M) added at seeding reduces the growth rate and saturation density of normal human embryonic lung fibrolasts of two lines (WI‐38 and IMR‐90) and similarly inhibits growth of SV40‐transformed WI‐38 cells (VAI3A). The growth inhibitory effects of retinoic acid do not show serum dependency, and the viability of treated cells is 95–99% of controls. Old populations of WI‐38 cells (cells at high population doubling levels) are more sensitive to the effects of retinoic acid than are young populations (cells at low population doubling levels), and population life span is reduced by continuous exposure to retinoic acid. When retinoic acid is combined with the gluococorticoid hydrocortisone, inhibition of VAI3A cell growth is increased, whereas the retinoic acid‐induced inhibition of normal cells is decreased. VA13A cells treated with retinoic acid alone, or in combination with hydrocortisone, exhibit a reversion to a more elongated, fibroblast‐like appearance. This paper discusses the clinical implications of the relationship between retinoic acid and hydrocortisone.
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