AbstractPrevention of adult AIDS cases should begin during childhood and adolescence. taking into account such issues as personal vulnerability, perceived control, and behavioral change. High-risk sexual and drug using behaviors in adolescents should be viewed within a developmental perspective, focusing on cognitive development (Piaget), psychosocial development (Erikson), and moral development in males (Kohlberg), females (Gilligan), and children (Damon). Public health educators have emphasized the high-risk behaviors of unsafe sex and needle sharing, with considerably less attention given to the role of alcohol and other drug intoxicationin the transmission of human immunodeficiency virus. Adolescents are often uncomfortable discussing sexual matters with their partners. Therefore, alcohol or other drugs may be used to reduce sexual anxiety. Such drug use prior to sexual activity may impair judgment, and risks may be taken that might not have been taken in a more sober condition.