Stability-Indicating Methods for the Determination of Cimetidine Using Derivative and Fourier-Transform Infrared Spectrophotometry
作者:
SoniaZ. El-Khateeb,
SawsanM. Amer*,
SawsanA. Abdel Razek,
MohamedM. Amer,
期刊:
Spectroscopy Letters
(Taylor Available online 1998)
卷期:
Volume 31,
issue 7
页码: 1415-1429
ISSN:0038-7010
年代: 1998
DOI:10.1080/00387019808001649
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Two different techniques, that is, second (D2) and third (D3) derivative spectrophotometry and fourier transform infrared (FTIR) Spectrophotometry, are investigated for the selective determination of the intact cimetidine in presence of up to 25% and 75% of its degradates, respectively. The procedures determine 2–10 jag ml−1at 224 nm and 217.5 nm by D2and D3, respectively, and 1–6 mg per 250 mg in K Br by the FTIR with mean accuracies of 100.0 ± 1.07%, 100.5 ± 0.87% and 100.3 ± 1.16%, respectively. The drug is successfully analysed in its pharmaceutical formulations.
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