TGF-βRegulates Production of Growth Factors and TGF-βby Human Peripheral Blood Monocytes
作者:
McCartneyNancy,
MizelDiane,
WongHenry,
WahlLarry,
WahlSharon,
期刊:
Growth Factors
(Taylor Available online 1990)
卷期:
Volume 4,
issue 1
页码: 27-35
ISSN:0897-7194
年代: 1990
DOI:10.3109/08977199009011007
出版商: Taylor&Francis
关键词: TGF-β;monocyte;cytokine
数据来源: Taylor
摘要:
AbstractTransforming growth factor beta 1 (TGF-β1) and its closely related homologue, TGF-β2, rapidly induce growth factor gene expression by freshly isolated human peripheral blood monocytes. Within 3 h of exposure to TGF-β, mRNA species specific for interleukin-1 (IL-1β), tumor necrosis factor-α(TNF-α), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) were observed. By 14-18 h, cytokine bioactivity and protein were detected in the culture supernatants. Furthermore, not only TGF-β1, but also TGF-β2 mRNA are expressed constitutively in unstimulated monocytes. However, in response to exogenous TGF-β(βl orβ2), only TGF-β1 gene expression is upregulated, and the expression of TGF-β2 mRNA is unchanged. This selective autoinduction of TGF-β1 appears to be controlled at both transcriptional and post-transcriptional levels. These paracrine and autocrine activities of TGF-βsuggest potential mechanisms through which an inflammatory response can be initiated and amplified. In addition, the TGF-βenhancement of growth factor generation may promote fibrosis and angiogenesis relevant to physiological tissue repair as well as pathological fibrotic sequelae.
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