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Confidence Bounds for Normal Means under Order Restrictions, with Application to Dose-Response Curves, Toxicology Experiments, and Low-Dose Extrapolation

 

作者: DavidA. Schoenfeld,  

 

期刊: Journal of the American Statistical Association  (Taylor Available online 1986)
卷期: Volume 81, issue 393  

页码: 186-195

 

ISSN:0162-1459

 

年代: 1986

 

DOI:10.1080/01621459.1986.10478258

 

出版商: Taylor & Francis Group

 

关键词: Isotonic regression;Confidence intervals

 

数据来源: Taylor

 

摘要:

Suppose thaty1, …,ykare normal random variables with ordered meansu1≤u2≤ … ≤uk. A confidence bound is found for eachuithat takes advantage of the ordering. The upper and lower bounds are the maximum and minimum values ofxsuch that the hypotheses thatx<uiandui<xare accepted by their respective likelihood ratio tests. These bounds are often more precise than the usual bounds and can be used to determine the safety of a toxin and to bound the virtual safe dose in a low-dose extrapolation. Simultaneous intervals foru1, …,ukare also derived.

 

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