Confidence Bounds for Normal Means under Order Restrictions, with Application to Dose-Response Curves, Toxicology Experiments, and Low-Dose Extrapolation
作者:
DavidA. Schoenfeld,
期刊:
Journal of the American Statistical Association
(Taylor Available online 1986)
卷期:
Volume 81,
issue 393
页码: 186-195
ISSN:0162-1459
年代: 1986
DOI:10.1080/01621459.1986.10478258
出版商: Taylor & Francis Group
关键词: Isotonic regression;Confidence intervals
数据来源: Taylor
摘要:
Suppose thaty1, …,ykare normal random variables with ordered meansu1≤u2≤ … ≤uk. A confidence bound is found for eachuithat takes advantage of the ordering. The upper and lower bounds are the maximum and minimum values ofxsuch that the hypotheses thatx<uiandui<xare accepted by their respective likelihood ratio tests. These bounds are often more precise than the usual bounds and can be used to determine the safety of a toxin and to bound the virtual safe dose in a low-dose extrapolation. Simultaneous intervals foru1, …,ukare also derived.
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