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The organospecific activity of six N‐nitroso compounds in the host‐mediated assay with yeast and rats

 

作者: Rudolf Fahrig,   Herbert Remmer,  

 

期刊: Teratogenesis, Carcinogenesis, and Mutagenesis  （WILEY Available online 1983）
卷期: Volume 3, issue 1  

页码: 41-49

 

ISSN:0270-3211

 

年代: 1983

 

DOI:10.1002/1520-6866(1990)3:1<41::AID-TCM1770030106>3.0.CO;2-R

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: host‐mediated assay;diethylnitrosamine;dibutylnitrosamine;N‐nitroso‐piperidine;N‐methyl‐N‐nitrosourethane;N‐methyl‐N‐nitroso‐urea;N‐methyl‐N′‐nitro‐N‐nitrosoguanidine

 

数据来源: WILEY

 

摘要:

AbstractThe organospecific activity of the N‐nitroso compounds diethylnitrosamine (DEN), dibutylnitrosamine (DBN), N‐nitroso‐piperidine, N‐methyl‐N‐nitrosourethane (NMUT), N‐methyl‐N‐nitroso‐urea (NMU), and N‐methyl‐N′‐nitro‐N‐nitroso‐guanidine (MNNG) has been studied in the host‐mediated assay by recovering yeast cells present in testes, liver, and lung of rats.All six substances were genetically active, and their organospecificity under host‐mediated assay conditions corresponded relatively well to their organospecific carcinogenic effects of single dose experiments, but n

 

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