Effect of L-Dopa on Plasma TSH Levels in Primary Hypothyroidism
作者:
M. Minozzi,
M. Faggiano,
G. Lombardi,
C. Carella,
T. Criscuolo,
U. Scapagnini,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 17,
issue 2
页码: 147-153
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122350
出版商: S. Karger AG
关键词: Hypothyroidism;TSH;L-dopa;Monoamines
数据来源: Karger
摘要:
Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations in plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypothyroidism L-dopa induced a biphasic response in plasma TSH. In fact, we observed a transitory increase with a maximum at 30 min (mean ± SEM = 54 ± 18%) followed by a decrease reaching a minimum level of plasma TSH basal values at 90 min (mean ± SEM = 15 ± 6%). These findings demonstrate that the plasma TSH response to L-dopa in primary hypothyroidism is time-dependent. Some speculation on the possible mechanism of this action is presen
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