β-Adrenergic Cardiac Antibody in Autoimmune Myocarditis
作者:
LeirosClaudia Perez,
BordaLeonor Sterin,
BordaEnri,
期刊:
Autoimmunity
(Taylor Available online 1989)
卷期:
Volume 2,
issue 3
页码: 223-234
ISSN:0891-6934
年代: 1989
DOI:10.3109/08916938909014686
出版商: Taylor&Francis
关键词: β-adrenergic receptors;myocarditis;autoimmunity;antibodies;cardiac contractility;antiβ-adrenergic;receptor antibody
数据来源: Taylor
摘要:
Balb/c mice were immunized with homologous heart in complete Freund's adjuvant to induce autoimmune myocarditis. The myocarditis was characterized by lymphomononuclear infiltration, electrocardiographic abnormalities and antimuscle antibodies by indirect immunofluorescence. In this paper, we demonstrate that the IgG present in autoimmune myocarditis mice is able to bind toβ-adrenoreceptors of the heart and also induce a biological effect inhibiting the contractile action of exogenous norepinephrine. Auto-immune IgG inhibited the binding of (3H)-dyhidroalprenolol to aβ-adrenergic receptor of purified myocardial membranes behaving as non-competitive inhibitor. This IgG also exerted a non-competitive inhibition upon the mechanical effect of exogenous norepinephrine. The recognition appears to be organ specific, because the autoimmune myocarditis IgG did not bind toβ-lymphocyte, lung and fat adrenoreceptors. The autoimmune IgG inhibited the stimulatory action of isoproterenol on cAMP levels, behaving as aβ-adrenergic antagonist.
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