Transforming mutations in protein—tyrosine kinase genes
作者:
Jonathan A. Cooper,
期刊:
BioEssays
(WILEY Available online 1986)
卷期:
Volume 4,
issue 1
页码: 9-15
ISSN:0265-9247
年代: 1986
DOI:10.1002/bies.950040104
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractOncogenes are altered forms of normal cellular genes known as proto‐oncogenes. Several oncogenes encode enzymes that phosphorylate substrate proteins at tyrosine. In most of these cases the oncogene differs from its proto‐oncogene by multiple mutations that alter the structure of the encoded protein product. Here we discuss how structural changes might effect the regulation and substrate specificity of the protein kinase product of a protooncogene so that it gains the potential to transform ce
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