Respiration of F344 rats in nose‐only inhalation exposure tubes
作者:
Joe L. Mauderly,
期刊:
Journal of Applied Toxicology
(WILEY Available online 1986)
卷期:
Volume 6,
issue 1
页码: 25-30
ISSN:0260-437X
年代: 1986
DOI:10.1002/jat.2550060106
出版商: John Wiley&Sons, Ltd.
关键词: rat;respiration;inhalation exposure;plethysmograph;inhalation toxicology;minute volume;breathing
数据来源: WILEY
摘要:
AbstractThe respiration of naive F344 rats confined in nose‐only inhalation exposure tubes was measured to obtain data for normal adult rats of different ages and to evaluate the tubes for exposures lasting several hours. Exposure tubes were modified for use as volume‐displacement plethysmographs. Respiration of 10 male and 10 female rats at 3, 6, 12 and 24 months of age was measured in the tubes during simulated exposures of up to 6 h duration. Measurements included respiratory frequency, tidal volume, minute volume and body surface temperature. The mean respiratory frequencies of 3, 6, 12 and 24 month old rats during the first hour of exposure were 172, 152, 123 and 136 breaths min−1, respectively. Minute volumes were 1.40, 089, 0.67 and 0.82 ml g−1body weight, respectively. Both frequency and minute volume g−1body weight were significantly greater for the youngest group, declined with age to 12 months and then increased at 24 months. Minute volumes g−1body weight were similar for males and females. Minute volume and respiratory frequency of 3 and 12 month old rats declined progressively between 1 and 6 h of confinement in the tubes. Surface temperature did not increase after the first hour. The age and sex‐specific data provide a basis for predicting respiration of naive tube‐confined rats during inhalation exposures to non‐irr
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