Sensitivity of the Fibrinogen Clotting Time: An in vitro Test of Potential Thrombogenicity
作者:
P.A. Feldman,
S. McGrath,
H. Evans,
期刊:
Vox Sanguinis
(WILEY Available online 1994)
卷期:
Volume 66,
issue 1
页码: 1-7
ISSN:0042-9007
年代: 1994
DOI:10.1111/j.1423-0410.1994.tb00268.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractThe fibrinogen clotting time (FCT) is a measure of thrombin activity, and is used to evaluate the potential thrombogenicity of prothrombin complex concentrates (PCC). We have defined end points for clot formation in this test which allow the measurement in PCC of thrombin concentrations as low as 0.001 IU/ml. The FCT of thrombin and PCC samples which did not contain antithrombin III (ATIII) were the same when measured at 20°C or 37°C. In the presence of ATIII (0.05 or 0.25 IU/ml), samples of PCC which were known to contain thrombin showed shorter FCT at 20°C than at 37°C. Inclusion of both ATIII (0.25 IU/ml) and heparin (4 IU/ml) in PCC ensured the complete inactivation of endogenous throm
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