Injury to Cultured Endothelial Cells: the Role of Lipoproteins and Thrombo-Active Agents
作者:
Stein A. Evensen,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 203-210
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214312
出版商: S. Karger AG
关键词: Cultured endothelial cells;Thrombin;Low density lipoproteins
数据来源: Karger
摘要:
Thrombin and low density lipoproteins (LDL) are capable of inducing damage to human endothelial cells in primary culture. These substances both induce endothelial contraction as first recognizable morphological change. However, the effect of thrombin appeared early, was reversible and prevented by hirudin, while LDL acted over hours and the injury was progressive. Addition and high density lipoprotein (HDL), together with LDL, inhibited the cellular injury induced by LDL.
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