Glycerol Therapy of Experimental Cerebral Microembolism
作者:
DENNIS WELCH,
REBECCA STUDER,
BARRY SIEGEL,
期刊:
Stroke
(OVID Available online 1974)
卷期:
Volume 5,
issue 4
页码: 439-443
ISSN:0039-2499
年代: 1974
出版商: OVID
关键词: brain edema, therapy;brain electrolytes;brain extracellular fluid;brain water;increased intracranial pressure;cerebral infarction
数据来源: OVID
摘要:
Glycerol was administered to control rats and to animals with experimental cerebral microembolism as a single intravenous injection (1 gm per kilogram), a single one-hour intravenous infusion (1.5 gm per kilogram), daily one-hour intravenous infusions (1 gm per kilogram), or in multiple oral doses (1 gm per kilogram per four hours). There were no effects of glycerol on the mortality, brain edema or increased brain sodium concentration and75Seselenate space due to cerebral microembolism. Brain water was not reduced in the hemispheres contralateral to embolization or in glycerol-treated controls. The results suggest that glycerol, at the dose levels reported to be beneficial in human cerebral infarction, is ineffective for cerebral dehydration.
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