Comparison of Renal Function Parameters in the Assessment ofcis-PIatin Induced IMephrotoxicity
作者:
A.J.W. Verplanke,
R.F.M. Herbert,
R. de Wit,
C.H.N. Veenhof,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 3
页码: 267-272
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187821
出版商: S. Karger AG
关键词: cis-Platin;Nephrotoxicity;Retinol-binding protein;Alanine aminopeptidase;β-Galactosidase;N-acetyl-β-D-glucosaminidase;Albumin;Total protein;Creatinine
数据来源: Karger
摘要:
The early renal function parameters (RFP), i.e. urinary alanine aminopeptidase (AAP), β-galactosidase (βGAL), N-acetyl-β-D-glucosaminidase (NAG), retinol-binding protein (RBP), albumin (ALB), total protein (TP) and the conventional RFP plasma creatinine were assessed in 8 patients before and during treatment with the nephrotoxic antitumor agent cis-platin. Plasma creatinine increased during treatment with cis-platin. In all patients, acute tubular damage was revealed by early RFP. Albumin and total protein excretion patterns suggested alterations in glomerular function. The cumulative change in RBP excretion was related to plasma creatinine concentrations following cis-platin administration. The present study demonstrates that urinary RBP is a valuable parameter for the early assessment of cis-platin-induced nephrotoxici
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