The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine
作者:
Yair Herishanu,
Michael Lishner,
Yona Kitay-Cohen,
期刊:
Anti-Cancer Drugs
(OVID Available online 2002)
卷期:
Volume 13,
issue 2
页码: 177-179
ISSN:0959-4973
年代: 2002
出版商: OVID
关键词: Dacarbazine;fulminant hepatitis;steroids
数据来源: OVID
摘要:
Dacarbazine (DTIC) is commonly used for the treatment of malignant melanoma and Hodgkin's disease. A very rare complication of this cytotoxic agent is acute vascular hepatic damage, e.g. veno-occlusive disease or Budd–Chiari syndrome. The pathophysiological mechanism involved seems to be an immune reaction. This complication is frequently fatal. We report a patient who developed severe hepatic failure following DTIC treatment who responded favorably to treatment with glucocorticosteroid.
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