Mucociuary clearance from the lungs of rabbits following single and intermittent exposures to ozone
作者:
RichardB. Schlesinger,
KevinE. Driscoll,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1987)
卷期:
Volume 20,
issue 1-2
页码: 125-134
ISSN:0098-4108
年代: 1987
DOI:10.1080/15287398709530966
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
This study examined the effects of ozone (O3) inhalation on mucociliary clearance from the tracheobronchial tree. Rabbits were exposed for 2 h at 0.1, 0.25, and 0.6 ppm or for 2 h/d for 74 consecutive days at 0.25 and 0.6 ppm. Clearance was assessed by measuring the retention of radioactivity tagged, inert tracer particles inhaled immediately after the single 2‐h exposure, or 24 h after 2, 7, or 14 of the daily exposures. Single exposures resulted in a concentration‐related trend toward retarded particle clearance, with a statistically significant difference occurring after exposure to 0.6 ppm. Intermittent exposures produced no significant change in clearance rate, although there was a suggestion of retarded clearance at early time points at both 0.25 and 0.6 ppm.
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