Effects of brain temperature on CBF thresholds for extracellular glutamate release and reuptake in the striatum in a rat model of graded global ischemia
作者:
Heng Zhao,
Satoshi Asai,
Tadashi Kohno,
Koichi Ishikawa,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 14
页码: 3183-3188
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cerebral blood flow (CBF);Cerebral ischemia;Dialysis electrode;Glutamate;Glutamate release;Glutamate re-uptake;Hyperthermia;Hypothermia;In vivo;Normothermia
数据来源: OVID
摘要:
WE simultaneously measured extracellular glutamate ([Glu]e) elevation and local CBF using a real-time monitoring method and laser-Doppler flowmetry, respectively, in the rat striatum in a modified graded global ischemia model. Ischemic brain temperatures were kept at 32°C, 37°C and 39°C. Three distinct types of intraischemic [Glu]e elevation, reflecting mild, moderate and massive glutamate release, were observed. Brain temperature plays an important role in determining CBF thresholds for each of the three types of [Glu]e elevation. CBF thresholds for [Glu]e elevations shifted to a lower level range as brain temperature was reduced. In mild or moderate ischemia, there is no exposure to sustained [Glu]e elevation, which is seen only in relatively severe ischemia characterized by biphasic [Glu]e elevation.
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