Distinguishing Spitz Tumors from Malignant Melanoma: Potential Role of Comparative Genomic Hybridization and Fluorescence In Situ Hybridization in Diagnosis and PrognosisOn: Mutations and copy number increase ofHRASin Spitz nevi with distinctive histopathological features. Bastian BC, LeBoit PE, Pinkel D.Am J Pathol2000;157:967–72
作者:
Keith Llewellyn,
Raymond Barnhill,
期刊:
Advances in Anatomic Pathology
(OVID Available online 2001)
卷期:
Volume 8,
issue 5
页码: 249-254
ISSN:1072-4109
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
The distinction of Spitz tumors from melanoma is a major challenge to pathologists at least for a subset of cases. Herein the authors review a recent study utilizing the techniques of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) to aid in the latter distinction. The limitations of the study and two techniques as applied to solid tumors are reviewed.
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