Biochemical effects of prolonged renin inhibition in marmosets
作者:
Jeanette Wood,
Ross Jobber,
Hans-Peter Baum,
Marc de Gasparo,
Jürg Nussberger,
期刊:
Journal of Hypertension
(OVID Available online 1989)
卷期:
Volume 7,
issue 8
页码: 615-618
ISSN:0263-6352
年代: 1989
出版商: OVID
关键词: Angiotensin II;aldosterone;primate;urea;sodium depletion;creatinine;angiotensin converting enzyme inhibition;minipump
数据来源: OVID
摘要:
The renin inhibitor CGP 29287 was administered continuously for 7 days (30mg/kg per day, intraperitoneally, via osmotic minipumps) to normotensive marmosets fed a low-salt diet. As a control, another group of marmosets was given vehicle only. After 7 days of treatment, the mean arterial blood pressure of the CGP29 287-treated marmosets was significantly lowered by about 23mmHg. Plasma immunoreactive total and active renin were increased 10- and sevenfold, respectively, whereas plasma renin activity (PRA) was reduced by 95%. Plasma angiotensin II (Ang II) and aldosterone were also reduced (by 97 and 85%, respectively). Serum angiotensin converting enzyme activity was unchanged and there were no differences in plasma concentrations of electrolytes, urea or creatinine between CGP29 287-treated and control marmosets. These results indicate that although renin release is markedly stimulated after continuous administration of a renin inhibitor for 7 days, the formation of Ang II and aldosterone, the active hormones of the renin-angiotensin system, is substantially reduced.
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