The electrochemical oxidation of gliclazide has been studied in Britton-Robinson buffers in the pH range of 2.0-12.0 by cyclic voltammetry and differential pulse polarography at carbon paste electrode. Gliclazide gave rise to two voltammetric peaks, corresponding to the oxidation of hydrazide –CO-NH-NR2moiety (where R2are cycloalkylamino ring). The oxidation process has been shown to be irreversible and diffusion-controlled with adsorption characteristics over the entire pH range. Analytical methods with adequate precision and accuracy have been developed for the voltammetric determination of gliclazide in tablets.