BIOACCUMULATION OF POLYCHLORINATED BIPHENYLS (PCBs) AND DICHLORODIPHENYLETHANE (DDE) METHYL SULFONES IN TISSUES OF SEAL AND DOLPHIN MORBILLIVIRUS EPIZOOTIC VICTIMS
作者:
G. M. Troisi,
K. Haraguchi,
D. S. Kaydoo,
M. Nyman,
A. Aguilar,
A. Borrell,
U. Siebert,
C. F. Mason,
期刊:
Journal of Toxicology and Environmental Health, Part A
(Taylor Available online 2000)
卷期:
Volume 62,
issue 1
页码: 1-8
ISSN:1528-7394
年代: 2000
DOI:10.1080/00984100050201622
出版商: Informa UK Ltd
数据来源: Taylor
摘要:
Polychlorinated biphenyl (PCB) and dichlorodiphenylethane (DDE) methyl sulfone (MSF) metabolites possess high affinities for binding two homologous 16,000 Da homodimeric receptor proteins in the lung (Clara cell secretory protein, CCSP) and the uterus (uteroglobin, UG), leading to selective bioaccumulation of MSFs in these tissues. As marine mammals are highly exposed to organochlorines, concentrations of PCBs, PCB MSFs, DDT, and DDE MSF were analyzed in blubber, lung, and uterus samples from harbor seal (Phoca vitulina) and striped dolphin (Stenella coeruleoalba
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