Inhaled Corticosteroids With/Without Long-Acting β-Agonists Reduce the Risk of Rehospitalization and Death in COPD Patients
作者:
Joan B. Soriano,
Victor A. Kiri,
Neil B. Pride,
Jørgen Vestbo,
期刊:
American Journal of Respiratory Medicine
(ADIS Available online 2003)
卷期:
Volume 2,
issue 1
页码: 67-74
ISSN:1175-6365
年代: 2003
出版商: ADIS
关键词: Beta adrenoceptor agonists, therapeutic use;Chronic obstructive pulmonary disease, treatment;Corticosteroids, therapeutic use
数据来源: ADIS
摘要:
IntroductionIn patients with COPD who have recently been hospitalized for their disease, we examined whether treatment with inhaled corticosteroids without or with long-acting β-adrenoceptor agonists (β-agonists) reduced rehospitalization and mortality.Study designRetrospective cohort analysis in the UK General Practice Research Database.MethodsWe compared rehospitalization for a COPD-related medical condition or death within 1 year after first hospitalization, in 3636 COPD patients receiving prescriptions for inhaled corticosteroids or long-acting β-agonists compared with 627 reference patients with COPD who were prescribed short-acting bronchodilators only.ResultsRehospitalization within a year occurred in 13.2% of the reference COPD patients, 14.0% of users of long-acting β-agonists only, 12.3% of users of inhaled corticosteroids only, and 10.4% of users of inhaled corticosteroids and long-acting β-agonists. Death within a year occurred in 24.3% of the reference COPD patients, 17.3% of users of long-acting β-agonists only, 17.1% of users of inhaled corticosteroids only, and in 10.5% of users of inhaled corticosteroids and long-acting β-agonists. In multivariate analyses the risk of rehospitalization or death was reduced by 10% in users of long-acting β-agonists only (NS), by 16% in users of inhaled corticosteroids only, and by 41% in users of combined inhaled corticosteroids and long-acting β-agonists (both p < 0.05).ConclusionUse of inhaled corticosteroids with/without long-acting β-agonists was associated with a reduction of rehospitalization or death in COPD patients.
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