Critical analysis of long‐term tests for carcinogenicity
作者:
J. R. P. Cabral,
期刊:
Food Additives & Contaminants
(Taylor Available online 1984)
卷期:
Volume 1,
issue 2
页码: 101-107
ISSN:0265-203X
年代: 1984
DOI:10.1080/02652038409385832
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The objective of long‐term carcinogenicity studies is to observe test animals for a major portion of their lifespan for the development of neoplastic lesions during or after exposure to various doses of a test substance given by an appropriate route. Studies of this type require careful planning and documentation of the experimental design, a high standard of pathology, good animal care and suitable statistical analysis. These requirements are well known and have not undergone major changes during recent years. Rather than giving details of these requirements, which can now be found in many publications, this paper attempts to indicate some of the problems involved in a long‐term carcinogenicity study.
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