Synthesis and NMR spectra of17oxygen enriched phenols
作者:
Shelton Bank,
Kathryn L. Longley,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1990)
卷期:
Volume 28,
issue 1
页码: 41-52
ISSN:0362-4803
年代: 1990
DOI:10.1002/jlcr.2580280106
出版商: John Wiley&Sons, Ltd.
关键词: [17O]Phenol;[17O]p‐Bromophenol;[17O]p‐Methoxyphenol;17O NMR Spectra
数据来源: WILEY
摘要:
AbstractAn efficient and convenient method of preparing17O enriched phenols is described. Aryl boronic acids are oxidized with17O enriched potassium hydroperoxide. The17O labeled potassium hydroperoxide is prepared from the autoxidation reaction of benzhydrol with17O enriched oxygen gas in the presence of potassium t‐butoxide. [0–17]Phenol, p‐bromo[0–17]phenol and p‐methoxy[0–17]phenol were prepared in good to modest overall chemical yields (40–60%) and high isotopic retention (82–90% from 16.8 atom %17O2starting material).17O NMR spectra of the three enriched phenols demonstrate the benefits of using enriched samples in reducing the total experiment time and greatly improving the signal‐to‐noise ratio compared to
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