Effects of a Prolactin-Secreting Pituitary Tumor on Hypothalamic, Gonadotropic and Testicular Function in Male Rats
作者:
C.A. Hodson,
J.W. Simpkins,
K.A. Pass,
C.F. Aylsworth,
R.W. Steger,
J. Meites,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 30,
issue 1
页码: 7-10
ISSN:0028-3835
年代: 1980
DOI:10.1159/000122966
出版商: S. Karger AG
关键词: Pituitary;Tumor;Prolactin;LHRH;Hypothalamus;Rat;Adrenal;Testosterone
数据来源: Karger
摘要:
The presence of a transplanted prolactin- and GH-secreting pituitary tumor (Furth MtT·W15) in inbred male rats resulted in increased hypothalamic LHRH and pituitary LH content, decreased serum LH and testosterone concentrations, and very high serum prolactin values. The pituitary tumor also inhibited LH release by the in situ pituitary in response to orchidectomy, or orchidectomy and adrenalectomy, and reduced the LH response to LHRH administration. Testes weight was significantly reduced and adrenal weight was significantly increased in the rats carrying pituitary tumors. These results suggest that the inhibitory effects of the transplanted pituitary tumor on LH and testosterone secretion were affected both a reduction in hypothalamic LHRH release and a reduced responsiveness of the pituitary to LHRH
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