Distribution of the 4F2 light chain, LAT1, in the mouse brain
作者:
Takashi Kageyama,
Tetsuya Imura,
Akinori Matsuo,
Nagahiro Minato,
Shun Shimohama,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 17
页码: 3663-3666
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: 4F2;CD98;LATI;Neurogenesis;System L
数据来源: OVID
摘要:
LATI (the 4F2-light chain I) is a component of the CD98 surface antigen which participates in multiple functions including amino acid transport, cell survival, cell fusion and integrin activation. We examined the distribution of LATI in the mouse brain using immunohistochemistry. LATI was expressed on the microvessels, the subfornical organ, the subcommissural organ, ventromedial nucleus of the hypothalamus, subgranular zone of the dentate gyrus, ependymal layer of the lateral ventricles, and the olfactory bulb. LATI-positive cells incorporated bromodeoxyuridine in the latter three regions where neurogenesis occurs in adult mouse brain, indicating that LATI is involved in neuronal cell proliferation, as well as in amino acid transport in these regions.
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