STUDY OF DNA INTERACTIONS WITH MELPHALAN, BUSULPHAN, AND ANALOGUES USING AN HPLC METHOD
作者:
A. Karikas,
V. Constantinou-Kokotou,
V. Magrioti,
G. Kokotos,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 2000)
卷期:
Volume 23,
issue 12
页码: 1859-1864
ISSN:1082-6076
年代: 2000
DOI:10.1081/JLC-100100457
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A simple reversed phase HPLC method suitable to study the interactions of alkylating agents with DNA is presented in this paper. DNA interaction is expressed as the % DNA peak size exclusion. The effects caused by the antitumor drugs melphalan, busulphan, and busulpan analogues on DNA were clearly observed through chromatographic data. The synthetic dimethanesulphonates of 2-tetradecyl-1,4-butanediol and 1,2-hexadecanediol were proved more potent than busulphan.
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