Hybrid peptide containing RGDF (Arg‐Gly‐Asp‐Phe) coupled with the carboxyterminal part of α2-antiplasmin capable of inhibiting platelet aggregation and promoting fibrinolysis
作者:
M. Udvardy,
D. Schwartzott,
K. Jackson,
P. McKee,
期刊:
Blood Coagulation and Fibrinolysis
(OVID Available online 1995)
卷期:
Volume 6,
issue 1
页码: 11-16
ISSN:0957-5235
年代: 1995
出版商: OVID
关键词: RGD peptides;antiplasmin;platelet aggregation;fibrinolysis;antithrombotic effects
数据来源: OVID
摘要:
The aim of this study was to synthesize and investigate hybrid peptides which contain the RGD (Arg-Gly-Asp) sequence coupled with lysine residues in special arrangements (antiplasmin carboxyterminal peptide) in an effort to simultaneously inhibit platelet aggregation and promote fibrinolysis. Thein vitrohaemostatic modifying properties of the synthesized peptides were tested by ADP-induced platelet aggregation, plasmin-generation tests and fibrin-clot lysis assays. The hybrid peptide RGDFAP, composed of RGDF (Arg-Gly-Asp-Phe) coupled to a synthetic peptide residue of the carboxyterminal part of antiplasmin (AP26) inhibited platelet activation and increased plasmin generation andin vitrofibrin-clot lysis.
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