ALLOGRAFT TOLERANCE INDUCTION IN ADULT MICE ASSOCIATED WITH FUNCTIONAL DELETION OF SPECIFIC CTL PRECURSORS
作者:
ESTHER TWUYVER,
W. KAST,
ROB MOOIJAART,
JOEP WILMINK,
CORNELIS MELIEF,
LEO DE WAAL,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 5
页码: 844-847
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
Rejection of H-2 class I bm 1 mutant skin allografts by B6 recipient mice is mediated by a population of CD8+anti-bm1 cytotoxic T-lymphocytes that produces and consumes its own T helper factor in response to bm1 skin allografts (dual function CTL).Previously we have demonstrated that transfusion of allogeneic lymphocytes across an H‐2 class I disparity induces specific long‐lasting skin allograft survival.We now show that intravenous injection of allogeneic spleen cells across the bml mutant disparity results in a temporary decrease of donor‐reactive CTLp in the spleen of recipient mice, lasting for approximately five weeks. The sponge matrix allograft model was used to show that allograft tolerance is caused by a specific functional clonal deletion of CTLp within the allograft. We propose that dual function CTL are vetoed by donor T cells, resulting in skin allograft tolerance.
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