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A Chemiluminescence Fiber-Optic Biosensor for Detection of DNA Hybridization

 

作者: Guojun Zhang,   Yikai Zhou,   Jinwei Yuan,   Shu Ren,  

 

期刊: Analytical Letters  （Taylor Available online 1999）
卷期: Volume 32, issue 14  

页码: 2725-2736

 

ISSN:0003-2719

 

年代: 1999

 

DOI:10.1080/00032719908543001

 

出版商: Taylor & Francis Group

 

关键词: DNA hybridization;fiber optics;chemiluminescence

 

数据来源: Taylor

 

摘要:

A novel fiber-optic DNA biosensor based on chemiluminescence is proposed. DNA probes were covalently immobilized onto the distal end of the optical fiber bundle. Hybridization of HRP (horseradish peroxidase)-labeled complementary nucleotides to the immobilized probes was detected by enhanced chemiluminescence. The detection limit (S/N=3) is 0.1 ppm. The approach is shown to be specific, sensitive and capable of diagnostic applications.

 

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