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Endocrine Control of Renal Handling of Solutes and Water in Vertebrates

 

作者: Hiroko Nishimura,  

 

期刊: Kidney and Blood Pressure Research  (Karger Available online 1985)
卷期: Volume 8, issue 4-5  

页码: 279-300

 

ISSN:1420-4096

 

年代: 1985

 

DOI:10.1159/000173060

 

出版商: S. Karger AG

 

关键词: Neurohypophysial hormones;Renin-angiotensin system;Adrenocortico-hormones;Prostaglandins;Prolactin;Catecholamines;Hormonal integration of renal function;Hormonal control of glomerular filtration;Hormonal control of tubular function

 

数据来源: Karger

 

摘要:

Hormones influence renal function by both extrarenal and intrarenal mechanisms. Extrarenal mechanisms include the effects through systemic hemodynamic and neural pathways, whereas intrarenal mechanisms can be largely divided into the effects on intrarenal hemodynamics and those on tubular transport epithelia. Neurohypophysial hormones and the renin-angiotensin system appear to act primarily on systemic and preglomerularvasculature in primitive vertebrates, while direct tubular action appears to have evolved at a later stage of phylogeny. Although aldosterone is an essential hormone for fluid mineral balance in mammals, the action of mineralocorticoids on tubular Na transport has not been established in nonmammalian tetrapods. In bony fishes in hyperosmotic environments, cortisol accelerates active Na extrusion from the gill. In contrast, prolactin is important for maintaining low osmotic water permeability of the transport epithelia in fishes in hypoosmotic media. Thus, both function and site of hormone action appear to have changed during the evolution of vertebrates interacting with changing environments, and in response to the demands from other bodily functions. Furthermore, evolution of interactions, at the cellular level, between systemic and locally formed hormones such as prostaglandins, kinins, and perhaps angiotensin may have developed more elaborate controlling systems of renal handling of solutes and water.

 

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