Interaction of alkali metals with unsaturated heterocyclic compounds. The reductive metallation of 2,3,5,6‐tetraphenylpyrazine and the synthesis of 1,2‐dihydro‐1,4‐diazine derivatives
作者:
Şeniz Kaban,
Nüket Öcal,
期刊:
Recueil des Travaux Chimiques des Pays‐Bas
(WILEY Available online 1996)
卷期:
Volume 115,
issue 7‐8
页码: 377-380
ISSN:0165-0513
年代: 1996
DOI:10.1002/recl.19961150707
出版商: WILEY‐VCH Verlag
数据来源: WILEY
摘要:
AbstractTreatment of 2,3,5,6‐tetraphenylpyrazine (1) with sodium in tetrahydrofuran effected the formation of monomeric dianion2. The chemical behaviour of this new disodium adduct was characterized by a variety of reagents. Generally, the protonation (water), alkylation (methyl iodide and benzyl chloride), and acylation (methyl and ethyl chloroformate) products were 1,2‐dihydrotetraphenyldiazine derivatives. An annulation of the pyrazine ring system was accomplished by treating the dianion with polymethylene chlorides, Cl(CH2)nCl,n= 2, 3
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