Prolactin causes increased turnover of dopamine in 10‐day‐old rat median eminence
作者:
William F. Silverman,
Raymond J. Walsh,
期刊:
The Anatomical Record
(WILEY Available online 1987)
卷期:
Volume 217,
issue 1
页码: 53-55
ISSN:0003-276X
年代: 1987
DOI:10.1002/ar.1092170108
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe present work examines the ability of prolactin to enter the CNS of the rat and effect its feedback stimulation of dopamine release prior to the appearance of prolactin receptors in choroid plexus (i.e., 10 days postnatal). An inhibitor of tyrosine hydroxylase was used to allow the assessment of dopamine turnover separate from synthesis and transport of the amine. Chronic but not acute hyperprolactinemia resulted in increased dopamine release relative to vehicle‐treated controls, as shown by diminished fluorescence intensity in the median eminence. These results indicate that activation of the prolactin short‐loop feedback system occurs by 10 days postnatal, prior to the appearance of prolactin receptors at the choroid ple
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