Pharmacokinetics of cefoperazone in horses
作者:
A. L. SORACI,
O. N. MESTORINO,
J. O. ERRECALDE,
期刊:
Journal of Veterinary Pharmacology and Therapeutics
(WILEY Available online 1996)
卷期:
Volume 19,
issue 1
页码: 39-43
ISSN:0140-7783
年代: 1996
DOI:10.1111/j.1365-2885.1996.tb00006.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
The pharmacokinetics and bioavailabilty of cefoperazone (CPZ) were studied following intravenous (IV) and intramuscular (IM) administration of single doses (30 mg/kg) to horses. Concentrations in serum, urine and synovial fluid samples were measured following IV administration. CPZ concentrations in serum, synovial fluid and spongy bone samples were measured following IM administration. After IV administration a rapid distribution phase (t1/2(α):4.22 ± 2.73 min) was followed by a slower elimination phase (t1/2(β) 0.77 ± 0.19 h). The apparent volume of distribution was 0.68 ± 0.10 L/kg. Mean synovial fluid peak concentration was 5.76 ± 0.74 μg/mL. After IM administration a bioavailability of 42.00±5.33% was obtained. Half‐life of absorption was 2.51 ± 0.72 min andt1/2(β)was 1.52±0.15 h. The mean synovial fluid and spongy bone peak concentrations at 2 h after IM administration were 2.91±0.85 μg/mL and 5.56±0.70 μg/
点击下载:
PDF
(439KB)
返 回