Effects of Antiepileptic Drugs on Hormones
作者:
R. Eugene Ramsay,
Jeremy D. Slater,
期刊:
Epilepsia
(WILEY Available online 1991)
卷期:
Volume 32,
issue 1
页码: 60-67
ISSN:0013-9580
年代: 1991
DOI:10.1111/j.1528-1157.1991.tb05894.x
出版商: Blackwell Publishing Ltd
关键词: Anticonvulsants;Drug‐induced abnormalities;Thyroid hormones;Steroid hormones;Contraceptives;Vitamin K;Glucose;Osteomalcia;Hyponatremia
数据来源: WILEY
摘要:
Summary:: A hormone is an intrinsic substance carried via the blood to a target organ which is then functionally stimulated. Similar to extrinsically administered medications, the metabolism and function of the hormones may be altered by antiepileptic drugs (AEDs). The proposed mechanisms are (a) enhanced metabolism (natural steroids, synthetic steroids, e.g., decadron and birth control pills, thyroxine, and vitamin D3), (b) altered protein bonding (thyroxine, sex hormones), (c) impaired release into the systemic circulation (calcitonin, insulin, vitamin K clotting factors) and (d) altered end‐organ effect. The AEDs most likely to interact with hormones are barbiturates, carbamazepine, and phenytoi
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