Very Late Activation-3 Integrin Is the Dominant β1-Integrin on the Glomerular Capillary Wall: An Immunofluorescence Study in Nephrotic Syndrome
作者:
Alberto Baraldi,
Luciana Furci,
Giovanna Zambruno,
Elisabetta Rubbiani,
Giorgio Annessi,
Egidio Lusvarghi,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 4
页码: 382-388
ISSN:1660-8151
年代: 1992
DOI:10.1159/000187085
出版商: S. Karger AG
关键词: Β1(very late activation) integrins;Very late activation-3 integrin;Glomeruli;Membranous nephropathy;Minimal change nephropathy
数据来源: Karger
摘要:
The expression of α2; α3; α5; α6-subunits of the β1 [very late activation (VLA)] integrin family was studied in kidney specimens using an immunofluorescent technique. 6 specimens from normal kidney were compared with 10 specimens from patients affected by various glomerulopathies [minimal change nephropathy (MCN), membranous nephropathy (MN) and systemic lupus erythematosus nephritis (SLEN)]. On normal glomeruli, α3 was the dominant integrin, being mainly present on podocytes and showing a linear fluorescent pattern codistributed with laminin. In MCN and SLEN, α3 presented a normal pattern. In MN, α3 revealed a trabecular picture on thickened glomerular basement membranes. Moreover, in stage-Ill MN, a segmental loss of α3-integrin was detected. In our opinion, VLA-3 may offer an interesting approach to the study of the relationships between podocytes and their s
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