Detection of human herpesvirus 8 DNA in semen from HIV‐infected individuals but not healthy semen donors
作者:
Mark Howard,
Denise Whitby,
Gulam Bahadur,
Fiona Suggett,
Chris Boshoff,
Melinda Tenant-Flowers,
Thomas Schulz,
Stuart Kirk,
Steve Matthews,
Ian Weller,
Richard Tedder,
Robin Weiss,
期刊:
AIDS
(OVID Available online 1997)
卷期:
Volume 11,
issue 2
页码: 15-19
ISSN:0269-9370
年代: 1997
出版商: OVID
关键词: Human herpesvirus 8;Kaposi's sarcoma;semen;sexual transmission
数据来源: OVID
摘要:
Objective:To ascertain the prevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus (HHV) type 8, and cytomegalovirus (CMV) DNA in semen was investigated.Methods:Amplification by nested polymerase chain reaction was used to detect viral DNA sequences in samples from 24 HIV-infected gay men, 15 of them with Kaposi's sarcoma (KS), and 115 healthy donors.Results:Six of the 24 HIV-infected patients had detectable HHV-8 DNA in their semen: three of the 15 patients with KS and three of the nine patients without KS. CMV DNA was detected in 20 semen samples from HIV-infected patients. None of the semen samples from healthy donors had detectable HHV-8 DNA and rates of CMV DNA detection were low (3%).Conclusions:The study demonstrates the presence of HHV-8 in semen from HIV-infected individuals with, or at risk, of developing KS and the potential for sexual transmission of the virus. We found no evidence of HHV-8 in the semen of HIV-uninfected donors.
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