Squamous cell carcinoma of the head and neck in nonsmokers: clinical and biologic characteristics and implications for management
作者:
Mark Lingen,
Erich Sturgis,
Merrill Kies,
期刊:
Current Opinion in Oncology
(OVID Available online 2001)
卷期:
Volume 13,
issue 3
页码: 176-182
ISSN:1040-8746
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
Squamous cell carcinoma of the head and neck has been strongly linked to chronic tobacco and alcohol abuse. However, we are increasingly recognizing subgroups of patients without traditional risk factors. Recent clinical and molecular investigations suggest that there are distinctive clinical entities, particularly affecting young patients with cancers of the oral tongue and oropharynx. We review data from clinical observations and current biologic inquiries and consider therapeutic implications for these important patient subgroups.
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