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Determination of Lamellar Body Phospholipids in Amniotic Fluid: A Method to Predict when the Fetal Lung Becomes Mature

 

作者: A. Beintema-Dubbeldam,   J. Bennebroek Gravenhorst,   J. Egberts,  

 

期刊: Gynecologic and Obstetric Investigation  (Karger Available online 1986)
卷期: Volume 21, issue 2  

页码: 64-69

 

ISSN:0378-7346

 

年代: 1986

 

DOI:10.1159/000298930

 

出版商: S. Karger AG

 

关键词: Lamellar bodies;Phospholipids;Surfactant;Fetal lung;Amniotic fluid;Maturation

 

数据来源: Karger

 

摘要:

Lamellar body material was isolated by highspeed centrifugation from the amniotic fluids of 10 mildly diseased patients followed longitudinally and of 60 other women. Three stages of development were defined: (1) immature stage: the phospholipid concentration is less than 20 µmol/l and phosphatidylcholine (PC) is approximately 50%; (2) transitional stage: the phospholipid concentration is between 18 and 40 µmol/l, of which PC is approximately 75% and phosphatidylinositol (PI) 10%. Phosphatidylglycerol (PG) is absent or present at very low concentrations; (3) mature stage: the phospholipid concentration is above 40 µmol/l; its PC percentage is 75% or more. PG is present and the percentage of PI decreases. An increase in phospholipid concentration of 3.27 ± (SD) 0.75 µmol/l/day was found during the transitional stage. The rate of increase enables us therefore to approximate the number of days that it will take before the fetal lung is ma

 

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